RESOURCES & RESEARCH
We are passionate about supporting our patients to take control of their health. This can mean many things from adopting a meditation practice to making dietary changes and of course, incorporating plant medicine. This page is a work in progress and will evolve as studies about cannabis and other lifestyle factors continue to be published. We hope this will be a guide for you to make choices about your body and to better understand the questions to ask when shopping for a cannabis product.
Cancer & the Entourage Effect / Whole Plant Medicine
Extensive preclinical research has demonstrated that cannabinoids, the active ingredients of Cannabis sativa, trigger antitumor responses in different models of cancer. Most of these studies have been conducted with pure compounds, mainly Δ9-tetrahydrocannabinol (THC). The cannabis plant, however, produces hundreds of other compounds with their own therapeutic potential and the capability to induce synergic responses when combined, the so-called “entourage effect”. Here, we compared the antitumor efficacy of pure THC with that of a botanical drug preparation (BDP). The BDP was more potent than pure THC in producing antitumor responses in cell culture and animal models of ER+/PR+, HER2+ and triple-negative breast cancer.
Anti-Cancer Properties of Cannabis
This review outlines some of the mechanisms that have been identified for CBD to inhibit tumor growth in several types of cancers and highlights the importance of exploring CBD and CBD analogues as potential therapeutic agents.
This study suggests that temozolomide together with combinations of THC and CBD – and specifically those containing a higher proportion of CBD – may have therapeutic potential in the treatment of glioblastoma.
Accumulating evidence indicates that cannabinoids have potent anti-tumor functions and might be used successfully in the treatment of glioblastoma. This review article summarizes the latest findings on the molecular effects of cannabinoids on glioblastoma, in in vitro and in pre-clinical studies in animal models and patients.
The study provides data that the Gi/ocoupled GPCR, GPR18, was activated by D9-THC and additional data showing that CBD acted as an antagonist at this same receptor. These results demonstrate that greater concentrations of D9-THC are required to activate GPR18 receptors, than of CBD to produce GPR18 antagonism, a difference that is likely to affect the therapeutic outcome of existing pharmacotherapies that combine both D9-THC and CBD.
Chemotherapy Induced Nausea and Vomiting
Chemotherapy-induced nausea and vomiting (CINV) remains an important issue for patients receiving chemotherapy despite guideline-consistent antiemetic therapy. Trials using delta-9-tetrahydrocannabinol-rich (THC) products demonstrate limited antiemetic effect, significant adverse events and flawed study design. Trials using cannabidiol-rich (CBD) products demonstrate improved efficacy and psychological adverse event profile.
This review provides animal and human research data on the current clinical neurological uses for CBD individually and in combination with Δ9-THC. It shows the neuroprotective, antiinflammatory, and immunomodulatory benefits of phytocannabinoids and their applications in various clinical syndromes.
Cannabidiol (CBD), the major non-psychotomimetic compound present in the Cannabis sativa plant, exhibits therapeutic potential for various human diseases, including chronic neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, ischemic stroke, epilepsy and other convulsive syndromes, neuropsychiatric disorders, neuropathic allodynia and certain types of cancer.
ENDOCRINE AND REPRODUCTIVE EFFECTS / SAFETY
This study showed that smoking cannabis has an estrogenic effect on the endocrine system, and that this effect is mostly caused not by the cannabinoid compounds themselves but by the complex ingredients generated by smoking marijuana.
Little is known about the reproductive effects of paternal cannabis exposure. This study evaluated associations between cannabis or THC exposure and altered DNA methylation in sperm from 12 male cannabis users and 12 non-users, as well as animal studies. Among other findings, in humans the researchers found that cannabis use altered sperm DNA methylation, although currently the effect of these alterations will require further study. Moreover, consistent with previous studies, they also found that men using cannabis had significantly lower sperm concentrations than non-users.
Human epidemiological and animal studies have found that prenatal cannabis exposure influences brain development and may have long-lasting impacts on cognitive functions of fetal development.
Dietary / Lifestyle Research